Cambridge Healthtech Institute’s 4th Annual

Covalent & Induced Proximity-Based Therapies

Innovative Chemistries and Assays for Studying and Modulating Cellular Interactions

April 14, 2025

Chemically induced proximity is an emerging area of interest, and covalent chemistries are often tapped into to trigger biological interactions, such as for protein degradation, protein stabilization, protein folding, chromatin regulation, and more. Cambridge Healthtech Institute’s symposium on Covalent & Induced Proximity-Based Therapies brings together academic and industry scientists from medicinal chemistry, chemical biology, and proteomics groups to discuss the innovative chemistries and technologies that can be leveraged to induce proximity for mechanistic studies, as well as for therapeutic intervention. It offers a preview of the topics that will be discussed in the conferences on Degraders & Molecular Glues as well as Protein-Protein Interactions that follow.

Coverage will likely include:

Utilizing innovative covalent chemistries for inducing proximity
Developments in emerging modalities that leverage proximity for designing new drugs
Advances in tools for modeling and predicting chemically induced proximity
Use of proximity inducers for dissecting kinetics and mechanisms of phosphorylation and other PTMs
Designing highly specific covalent drugs with less side effects
Reducing sensitivity of a covalent candidate to drug-resistant mutations

The deadline for priority consideration is September 27, 2024.

All proposals are subject to review by session chairpersons and/or the Scientific Advisory Committee to ensure the overall quality of the conference program. Additionally, as per Cambridge Healthtech Institute’s policy, a select number of vendors and consultants who provide products and services will be offered opportunities for podium presentation slots based on a variety of Corporate Sponsorships.

Opportunities for Participation: