Cambridge Healthtech Institute’s 2nd Annual
Next-Gen Degraders & Molecular Glues
New Modalities, Targets, Ligases for Inducing Proximity and Degradation
11-12 November 2025
Hetero bifunctional molecules like proteolysis-targeting chimeras (PROTACs), monovalent and bivalent molecular glues, and novel modalities and conjugates are being developed to seek out new targets for therapeutic intervention. They are tapping into new ligases and pathways for degradation to turn previously “undruggable” targets into “yet-to-be-drugged” targets for drug discovery. Cambridge Healthtech Institute’s conference on Next-Gen Degraders & Molecular Glues will bring together chemists, biologists, and PKPD experts who discuss new findings and opportunities they see in this exciting area of research.
Coverage will include, but is not limited to:
- Innovative chemistries and design strategies for PROTACs and molecular glues
- Exploring covalent chemistries and induced proximity
- Design of degrader conjugates and tools and rules for linker design
- Structural and mechanistic studies for understanding mechanism of degradation
- Emerging tools and assays to study novel E3 ligases and unexplored pathways
- Going beyond E3 ligases
- Improving efficacy and tissue specificity of novel modalities
- Tackling ADME/DMPK challenges with stability, biodistribution, oral availability
- Advances in formulation, delivery, and safety/toxicity assessments
- AI/ML tools for optimising ternary complex formation and degradation
- Pursuing challenging drug targets and non-oncology applications
The deadline for priority consideration is 4 April 2025.
All proposals are subject to review by session chairpersons and/or the Scientific Advisory Committee to ensure the overall quality of the conference program. Additionally, as per Cambridge Healthtech Institute’s policy, a select number of vendors and consultants who provide products and services will be offered opportunities for podium presentation slots based on a variety of Corporate Sponsorships.
Opportunities for Participation: